2018 – present  Member of the Scientific Advisory Board of Merus, Utrecht Genetic Background Generation; F?+F23 (2020-01-20 00:00:00) Gt(ROSA)26Sor tm1(CAG-Brainbow2.1)Cle. Celebrating 100 years of Developmental Biology at the Hubrecht Institute 2016    The Academy Professor Prize of the Royal Netherlands Academy Nature 435: 959-963 (2005), 21)           Batlle, E., Bacani, J., Begthel, H., Jonkheer, S., Gregorieff, A., van de Born, M., Malats, N., Sancho, E., Boon, E., Pawson, T., Gallinger, S., Pals, S., Clevers, H. EphB activity suppresses colorectal cancer progression. 2012    Knight in the Order of the Netherlands’ Lion Review 11 Oncode Institute, Hubrecht Institute-KNAW and UMC Utrecht, Utrecht, The Netherlands h.clevers@hubrecht.eu. Utrecht Science Park is only 15 minutes away from downtown Utrecht: a lively, charming university town. Cell 175:1591-1606 (2018), 56)           Gehart, H., van Es, J., Hamer, K., Beumer, J., Kretzschmar, K., Dekkers, J.F., Rios, A., and Clevers, H. Identification of enteroendocrine regulators by real-time single-cell differentiation mapping 54)           Roerink S.F., Sasaki N., Lee-Six H., Young M.D., Alexandrov L.B., Behjati S., Mitchell T.J., Grossmann S., Lightfoot H., Egan D.A., Pronk A., Smakman N., van Gorp J., Anderson E., Gamble S.J., Alder C., van de Wetering M., Campbell P.J., Stratton M.R., Clevers H. Intra-tumour diversification in colorectal cancer at the single-cell level. European Molecular Biology Laboratory (EMBL) About. And Clevers, H. Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H . From 2002-2012 he was director of the Hubrecht Institute in Utrecht and from 2012-2015 he was President of the Royal … Science 340: 1190-1194 (2013), 41)           Clevers, H. The intestinal crypt, a prototype stem cell compartment. Hubrecht Institute: promotional video. 2016 – present  Member of the Scientific Advisory Board of the Francis Crick Institute, London 2 Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, Netherlands. Clevers was the first to identify living stem cells in the intestine and is one of the world's leading researchers on adult stem cells, their role in cancer and their potential for regenerative therapy. Science  358: 234-238 (2017). of Immunology, Faculty of Medicine, 2002 – 2012      Director Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, 2002 – 2020      Professor in Molecular Genetics at University Medical Center Utrecht, 2002 – present  Principal Investigator of a research group of ~40 scientists at Hubrecht Institute, Utrecht, 2012 – 2015      President of the Royal Netherlands Academy of Sciences (KNAW), Amsterdam, 2014 – 2020      Chief Scientific Officer of HUB Organoids Technology, Utrecht, 2015 – 2019      Chief Scientific Officer/Director Research of the Princess Máxima Center, Utrecht, 2015 – present  Principal Investigator at the Princess Máxima Center, Utrecht, 2000    Catharijne prize for medical research, 2001    Award from the European Society for Clinical Investigation, 2001    Spinoza Award of the Netherlands Research Council (NWO), 2004    Louis-Jeantet Prize for Medicine, Geneva, Switzerland, 2005    The Science and Society Prize, Amsterdam, 2005    The French honor of “Chevalier de la Legion d’Honneur”, 2005    Katharine Berkan Judd Award, New York, 2006    Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research, Jerusalem, 2008    Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam), 2008    Meyenburg Cancer Research Award, Germany, 2009    The Queen Wilhelmina Dutch Cancer Society Award, Amsterdam, 2010    The United European Gastroenterology Federation (UEGF) Research Prize, 2011    The Ernst Jung Medical Award, Germany, 2012    Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize, Paris, 2012    William Beaumont prize of the American Gastroenterology Association, 2012    Knight in the Order of the Netherlands’ Lion, 2013    The Breakthrough Prize in Life Sciences, 2013    International Dream Team (with Hans Bos) by Dutch Cancer Society (KWF), 2014    Massachusetts General Hospital Award in Cancer Research, 2014    TEFAF Oncology Chair 2014, Maastricht, 2014    Struyvenberg European Society for Clinical Investigation (ESCI) medal, 2015    ISSCR-McEwen Award for Innovation, 2016    The Academy Professor Prize of the Royal Netherlands Academy, 2016    Kazemi Award for Research Excellence in Bio-Medicine, 2016    The Körber European Science Prize, Germany, 2016    The Ilse & Helmut Wachter award, Hamburg, Germany, 2017    Princess Takamatsu Award of Merit, Tokyo, 2018    Großes Verdienstkreuz mit Stern, Germany, 2018    Academia Europaea Erasmus Medal, Barcelona, Spain, 2019    Citation Laureate, Web of Science Group, 2008 – 2015      Louis Jeantet Prize, Geneva, 2013 – 2015      Canada Gairdner Award, Toronto, 2014 – present  Breakthrough Prize in Life Sciences, San Francisco, 2015                     Pezcoller Foundation – AACR International Award for Cancer Research, Italy, 2015                     Dr. Paul Janssen Award, Bruxelles, 2017 – present  Francqui Prize, Bruxelles, 2017                     Kovalenko Medal, National Academy of Sciences Washington, 2002 – present  Central South University, Chang Sha, China, 2014 – 2015      TEFAF Oncology Chair, Maastricht, 2015 – 2016      Visiting professor, Weizmann Institute, Rehovoth, Israel, 2016 – present  Distinguished Visiting Professor, University of Hong Kong, 2015 – present  Visiting professor, University of Melbourne, Australia, 2019 – present  Honorary Director, Fudan Organoid Center, Fudan University, Shanghai, 2019 – present  Foreign Advisory Board Member of Consortium for Neogenetic Medicine, Tokyo, 1999               Member European Molecular Biology Organisation (EMBO), 2000               Member of the Royal Netherlands Academy of Sciences (KNAW), 2009               Member of the Academia Europaea, 2012               Member of the American Academy of Arts and Sciences, 2012               Member of the Royal Netherlands Society of Sciences and Humanities, 2014               Member of the National Academy of Sciences of the USA, 2016               Member of the Academie des Sciences de I’Institut de France, 2017               Member of the Orden Pour le Mérite für Wissenschaften und Künste, Germany, 2019               Foreign Member of the Royal Society, London, United Kingdom, 2019               Honorary Fellow of the Royal Society of Edinburgh, Scotland, 2005 – 2015      Member Scientific Advisory Board of Swiss Institute for Experimental Cancer Research, Lausanne, 2006 – 2008      President of the International Society of Differentiation (ISD), 2007 – 2010      Member of the National Scientific Advisory Board NKI-AVL, Amsterdam, 2012 – 2015      Member of the Board of the American Association of Cancer Research, 2015 – present  Member of the Scientific Advisory Board of the Institute of Molecular Pathology, Vienna, 2016 – 2020      Member of the Scientific Advisory Board of Kallyope, New York, 2016 – present  Member of the Scientific Advisory Board of the Francis Crick Institute, London, 2016 – present  Member of the Scientific Advisory Board of Decibel Therapeutics, Boston, 2016 – present  Member of the Scientific Advisory Board of Surrozen, San Francisco, 2017 – 2018      President of the International Society for Stem Cell Research (ISSCR), 2018 – present  Member of the Scientific Advisory Board of Merus, Utrecht, 2018 – present  Scientific advisor Life Science Partners, Amsterdam, 2019 – present  Non-executive member of the Board of Directors of Roche Holding Ltd, Basel, 2020 – present  Member of the Board of Directors of Genentech, South San Francisco, 2020 – present  Member of the Board of Genentech, South San Francisco, 2020 – present  Member of the Scientific Advisory Board of Volestra Therapeutic Inc., New York, 2020 – present  Chair of the Scientific Advisory Board DImed Inc., Shanghai, 2020 – present  Chair of the Scientific Advisory Board of Xilis, at Duke University (NC), SARS-CoV-2 productively Infects Human Gut Enterocytes, Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli, An organoid platform for ovarian cancer captures intra- and inter-patient heterogeneity, Tubuloids derived from human adult kidney and urine for personalized disease modeling, Identification of enteroendocrine regulators by real-time single-cell differentiation mapping, Long-term expansion of functional mouse and human hepatocytes as 3D organoids, Intra-tumour diversification in colorectal cancer at the single-cell level. The discovery of Lgr5 as a generic marker of Wnt-dependent stem cells within multiple adult tissues has led to the development of technology to grow these stem cells into ever-expanding epithelial organoids. The Clevers group studies the biology of Wnt signaling in tissue turnover and in cancer. Oncode Institute 2015 – present  Visiting professor, University of Melbourne, Australia 2019    Citation Laureate, Web of Science Group, 2008 – 2015      Louis Jeantet Prize, Geneva M., Li, V.S., Jose, A., Hatzis, P., Mokry, M., Haegebarth, A., van den Born, M., Chambon, P., Voshol, P., Dor, Y., Cuppenm E., Fillat, C., Clevers, H. van Es, J.H., Sato, T., van de Wetering, M., Lyubimova, A., Yee Nee, A.N., Gregorieff, A., Sasaki, N., Zeinstra, L., van de Born, M., Korving, J., Martens, A.C., Barker, N., van Oudenaarden, A., Clevers, H. Schepers, A.G., Snippert, H.J., Stange, D.E., van den Born, M., van Es, J.H., van de Wetering, M., Clevers, H. Koo, B-K., Spit, M. Jordens, I., Low, T.Y., Stange, D.E., van de Wetering, M., van Es, J.H., Mohammed, S., Heck, A.J.R., Maurice, M.M. Nature 521: 43-47 (2015), 50)           Farin, H.F., Jordens, I., Mosa, M.H., Basak, O., Korving, J., Tauriello, D.V.F., de Punder, K., Angers, S., Peters, P.J. Cell 127 (3), 469-480, 2006. Maurice, M.M. 10 The Princess Maxima Center for Pediatric Oncology, Utrecht, … (2)Hubrecht Institute for Developmental Biology and Stem Cell Research, Oncode Institute, University Medical Centre Utrecht, Upsalalaan 8, 3584CT Utrecht, The Netherlands; Princess Máxima Center for Pediatric Oncology, 3584CT Utrecht, The Netherlands. The Hubrecht is a highly dynamic, diverse and young institute where the average age of the researchers is around 30 and more than 30 different nationalities are represented. Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute. Wnt signaling intimately interacts with the BMP and Notch cascades to drive proliferation and inhibit differentiation in intestinal crypts and adenomas (17, 20). For example, during the last year more than half of the top publications from the Hubrecht Institute involved more than two Hubrecht groups, demonstrating the collaborative spirit. A magnet for young talent. 2006 – 2008      President of the International Society of Differentiation (ISD) Reads . The Hubrecht Institute and PMC collaborate, especially using tumor organoids, single cell sequencing and intravital imaging of tumors. Cell 159:163-175 (2014), 46)           Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M., Ellis, E., van Wenum, M., Fuchs, S., de Ligt, J., van de Wetering, M., Sasaki, N., Boers, S., Kemperman, H., de Jonge, J. IJzermans, J., Niewenhuis, E., Hoekstra, R., Strom, S., Vries, R., van der Laan, L., Cuppen, E., Clevers, H. Long-term culture of genome-stable bipotent stem cells from adult human liver. 3 Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands. Present members are: Prof. Dr. Christine Mummery, Leiden University Medical Center, Leiden (chair) 2014 – 2015      TEFAF Oncology Chair, Maastricht Nature 476: 293-297 (2011), 34)           Li, V.S., Ng, S.S., Boersema, P.J., Low, T.Y., Karthaus, W.R., Gerlach, J.P., Mohammed, S., Heck, A.J., Maurice, M.M., Mahmoudi, T. and Clevers H. Wnt signaling inhibits proteasomal β-catenin degradation within a compositionally intact Axin1 complex. Nature Genetics 19: 379 383 (1998), 9)              Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destree, O., and Clevers, H. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. 2018    Academia Europaea Erasmus Medal, Barcelona, Spain Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or … Among other things, a celebratory issue of Developmental Biology was published. The Hubrecht Institute was named after Ambrosius Arnold Willem Hubrecht (1853-1915), professor of Zoology in the Faculty of Medicine of Utrecht University. Dr. Clevers received his M.D. h.clevers@hubrecht.eu. Since 2008, the Hubrecht is affiliated with the UMC Utrecht. The Clevers group studies the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells. All of these PhD students are affiliated with the Cancer, Stem Cells and Developmental Biology (CS&D) program of the Graduate School of Life Sciences (GSLS). The Dutch Cancer Society (KWF), the ministries of Economic Affairs and Climate Policy (EZK), Education, Culture and Science (OCW) and Health, Welfare and Sports (VWS), Health~Holland, NWO and ZonMw invest 120 million euros in Oncode Institute. 2019 – present  Foreign Advisory Board Member of Consortium for Neogenetic Medicine, Tokyo, 1999               Member European Molecular Biology Organisation (EMBO) Hans Clevers ‡ Hubrecht Institute, Koninklijke Nederlandse Akademie van Wetenschappen, and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands. In the UMC Utrecht, research is concentrated in six programs with each a limited number of disease targets. Dr. Clevers is a Professor of Molecular Genetics at Hubrecht Institute, Utrecht, The Netherlands. Prof. Dr. Michiel Vermeulen, Radboud University, Nijmegen. Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box. The Wnt target gene encoding the transcription factor Achaete scute-like 2 controls the fate of the intestinal stem cell (26). Nature Genetics 40: 1291-1299 (2008), 25)           Barker, N., Ridgway, R.A., van Es, J.H., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A.R., Sansom, O.J., Clevers, H. Crypt Stem Cells as the Cells-of-Origin of Intestinal Cancer. Between 2002 and 2012 he served as Director of the Hubrecht Institute for Stem Cell Research. 2011    Kolff prize, Amsterdam 2014    Fellow of the AACR Academy Tumour suppressor RNF43 is a stem cell E3 ligase that induces endocytosis of Wnt receptors. Gijs van den Brink: Tackling chronic inflammatory bowel disease. and Clevers, H. Intestinal Crypt Homeostasis results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells. Organoid models of human and mouse ductal pancreatic cancer. He is also University Professor at the University Utrecht and Oncode Investigator. Oncode Institute is a virtual, independent research institute dedicated to outsmarting cancer and impacting lives. E-mail: h.clevers{at}hubrecht.eu ↵ * These authors contributed equally to this work. These organoids recapitulate many aspects of their tissue of origin and allow the study of a multitude of physiological and pathological processes. ↵ ‡ To whom correspondence should be addressed. 32)           Snippert, J., van der Flier, L.G., Sato, T., van Es, J.H., van den Born, M., Kroon-Veenboer, C., Barker, N.,Klein, A.M., van Rheenen, J. Benjamin D. Simons, B.D. Utrecht University is an international research university of the highest quality and the alma mater of many leading names, academics and scientists who have made an important contribution to the quality of society. Since 2008, the Hubrecht is … Technology is transferred to society as efficiently as possible. and Clevers, H.C. van de Wetering, M., Oosterwegel, M., Dooijes, D., and Clevers, H.C. Hans Clevers is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center for Pediatric Oncology. Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer. The Tcf4-driven target gene program in colorectal cancer cells is the malignant counterpart of a physiological gene program in selfrenewing crypts (13, 14, 21). It promotes quality in science and scholarship and strives to ensure that Dutch scholars and scientists contribute to cultural, social and economic progress. 5,898. degree in 1984 and his Ph.D. degree in 1985, both from the University of … h.clevers@hubrecht.eu. The impact score places the Hubrecht also as one of the premier biology research institutes world-wide. M., van den Born, M., Begthel, H., Vries, R.G., Stange, D.E., Toftgård, R., Clevers, H. Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., and Clevers, H. van der Flier, L.G., van Gijn, M.E., .., and Clevers, H. Barker N., Ridgway R.A., van Es J.H.,van de Wetering M., Begthel H., van den Born M., Danenberg E., Clarke A.R., Sansom O.J., Clevers, H. Jaks V., Barker N., Kasper M., van Es J.H., Snippert H.J., Clevers H., Toftgård, R. Barker, N, van Es, J.H., Kuipers, J., Kujala P., van den Born, M., Cozijnsen, M., Korving, J., Begthel, H., Peters, P.C., and Clevers, H. Batlle E., Bacani J., Begthel H., Jonkheer S., Gregorieff A., Van de Born M., Malats N., Sancho E., Boon E., Pawson T., Gallinger S., Pals S., Clevers, H. Van Es J.H., Van Gijn M.E., Riccio O., Van den Born M., Vooijs M., Begthel H., Cozijnsen M., Robine S., Winton D.J., Radtke F., Clevers, H. Haramis A.P., Begthel H., van den Born M., van Es J., Jonkheer S., Offerhaus G.J., Clevers H. Baas A.F., Kuipers J., van der Wel N.N., Batlle E., Koerten H.K., Peters P.J., Clevers H.C. Hurlstone A.F., Haramis A.P., Wienholds E., Begthel H., Korving J., Van Eeden F., Cuppen E., Zivkovic D., Plasterk R.H., Clevers H. Battle, E., Henderson, J.T., Beghtel, H., van den Born, M., Sancho, E., Huls, G., Meeldijk, J., Robertson, J., van de Wetering, M., Pawson, T., Clevers, H. Van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., Van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A-P., Tjon-Pon-Fong, M., Moerer, P., Van den Born, M., Soete, G., Pals, S., Eilers, M., Medema, R., Clevers, H. Korswagen, R., Herman, M. and Clevers, H. Roose, J., Huls, G., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., and Clevers, H. Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destree, O., and Clevers, H. Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P.J. 2014 – present  Breakthrough Prize in Life Sciences, San Francisco Cell 149: 1245-1256 (2012), 35)           Koo, B-K., Spit, M. Jordens, I., Low, T.Y., Stange, D.E., van de Wetering, M., van Es, J.H., Mohammed, S., Heck, A.J.R., Maurice, M.M. Articles Cited by. Utrecht University is the largest university of the Netherlands, with 7 faculties, 6700 staff members, 600 professors, 550 PhD graduations per year, and 30.000 bachelor and master students. In the UMC Utrecht, research is concentrated in six programs with each a limited number of disease targets. Nature 507: 362-365 (2014), 45)           Karthaus, W.R., Iaquinta, P.J., Drost, J., Gracanin, A., van Boxtel, R., Wongvipat, J., Dowling, C.M., Gao, D., Begthel, H., Sachs, N., Vries, R.G., Cuppen, E., Chen, Y., Sawyers, C.L., Clevers, H.C. h.clevers@hubrecht.eu. 2017               Member of the Orden Pour le Mérite für Wissenschaften und Künste, Germany Read More + Genetic overview. 2015 – 2019      Chief Scientific Officer/Director Research of the Princess Máxima Center, Utrecht ↵ † Present address: … Nature 395: 608-612 (1998), 10)           Roose, J., Huls, G., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., and Clevers, H. Synergie between tumor suppressor APC and the beta-catenin/Tcf4 target gene Tcf1. 1991 – 2002      Professor and Chairman, Dept. Cell 160: 299-312 (2015), 47)           Boj, S.F., Hwang, C.I., Baker, L.A., Chio, I.I., Engle, D.D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M.S., Gracanin, A., Oni, T., Yu, K.H., van Boxtel, R., Huch, M., Rivera, K.D., Wilson, J.P., Feigin, M.E., Öhlund, D., Handly-Santana, A., Ardito-Abraham, C.M., Ludwig, M., Elyada, E., Alagesan, B., Biffi, G., Yordanov, G.N., Delcuze, B., Creighton, B., Wright, K., Park, Y., Morsink, F.H., Molenaar, I.Q., Borel Rinkes, I.H., Cuppen, E., Hao, Y., Jin, Y., Nijman, I.J., Iacobuzio-Donahue, C., Leach, S.D., Pappin, D.J., Hammell, M., Klimstra, D.S., Basturk, O., Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA. 2009    The Queen Wilhelmina Dutch Cancer Society Award, Amsterdam 2014    Massachusetts General Hospital Award in Cancer Research The scientific advisory board of the Hubrecht Institute meets once a year and is involved in the tenure track evaluations of the junior PI’s. Technologies including organoid technology, single-cell sequencing, and non-invasive prenatal testing were all developed at the Hubrecht Institute and are now implemented with our help at many other institutes and universities in the Netherlands. Utrecht Life Sciences is a platform that supports collaboration and innovation. On the shoulders of Hubrecht: From embryos to stem cells. 2014    TEFAF Oncology Chair 2014, Maastricht As such, they can attend the complete range of courses organized by the PhD Course Center. 2014               Member of the National Academy of Sciences of the USA Research at the Hubrecht Institute is diverse and covers many aspects of developmental and stem cell biology including signaling in stem cells and early development, cardiac development, regeneration, epigenetics, genome architecture, cell cycle control, DNA repair, gene expression dynamics and quantitative biology of gene expression. Presently, the Hubrecht Institute supports 23 research groups with a total of around 280 employees. 5 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, University Medical Center Utrecht , Utrecht, the Netherlands. About Us. He lived at the Janskerkhof in Utrecht, an official residence that later also contained the Anatomy/Embryology Laboratory and the Anatomy Museum of Utrecht University. Nature Biotechnology, 37:303-313 (2019), 58)          Tuveson D, Clevers H. Cancer modeling meets human organoid technology. Review. Cell 111: 251-263 (2002), 15)           Hurlstone, A.F., Haramis, A.P., Wienholds, E., Begthel, H., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R.H., Clevers, H. The Wnt/beta-catenin pathway regulates cardiac valve formation. Therefore, we provide PDF files of all publications on our website for personal use. Hubrecht Organoid Technology or HUB was founded around Organoid Technology. A springboard for senior group leaders. 10 Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Hubrecht Organoid Technology. The Hubrecht Institute collaborates with numerous laboratories, internationally, nationally and locally, always aiming to improve our research. h.clevers@hubrecht.eu. In the 1960’s, the Hubrecht Laboratory moved to a new building in the Uithof of Utrecht (nowadays called Utrecht Science Park the Uithof). 2016    Swammerdam medal, Amsterdam The institute encompasses 23 research groups that perform fundamental, multidisciplinary research on healthy and diseased cells, tissues and organisms. Research at the Hubrecht Institute focuses on developmental biology and stem cells at the organismal, cellular, and molecular level. Ushering in a new era of personalised medicine and drug development, Dutch molecular geneticist Hans Clevers and teams at the Hubrecht Institute and the University Medical Center (UMC) in Utrecht pioneered so-called "organoids". After completing his postdoctoral research between 1986 and 1989 at the Dana-Farber Cancer Institute at Harvard University, Clevers established his own laboratory for genetic research at Utrecht University. The institute encompasses 23 research groups that perform fundamental, multidisciplinary research on healthy and diseased cells, tissues and organisms. 2015                     Pezcoller Foundation – AACR International Award for Cancer Research, Italy Developmental Biology and Stem Cell Research During the last five years this interdisciplinary approach strengthened significantly. Nature 556, 437-462 (2018). 2015                     Dr. Paul Janssen Award, Bruxelles Nature Cell Biology 14: 1099-1104 (2012), 38)           Boj, S,F., van Es, J.H.,Huch. Modeling development and disease with organoids, Sequential cancer mutations in cultured human intestinal stem cells, Visualization of the short-range Wnt gradient in the intestinal stem cell niche, Prospective derivation of a ‘Living Organoid Biobank’ of colorectal cancer patients, Organoid models of human and mouse ductal pancreatic cancer, Long-term culture of genome-stable bipotent stem cells from adult human liver, Identification of multipotent luminal progenitor cells in human prostate organoid cultures, Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo imaging, Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients, Differentiated Troy+ chief cells act as ‘reserve’ stem cells to generate all lineages of stomach epithelium, The intestinal crypt, a prototype stem cell compartment, Growing self-organizing mini-guts from a single intestinal stem cells: mechanism and applications, In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration, Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand, DII (+) secretory progenitor cells revert to stem cells upon crypt damage, Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas, Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors, Lgr5 homologues associate with Wnt receptors and mediate R-spondin signaling, Wnt signaling inhibits proteasomal β-catenin degradation within a compositionally intact Axin1 complex, Intestinal Crypt Homeostasis results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells, Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts, Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin, Lgr5+ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro, Single Lgr5 gut stem cells build crypt-villus structures in vitro without a mesenchymal niche, Transcription factor Achaete scute-like 2 (Ascl2) controls intestinal stem cell fate, Crypt Stem Cells as the Cells-of-Origin of Intestinal Cancer, Lgr5 marks cycling, yet long-lived, hair follicle stem cells, Identification of Stem Cells in Small Intestine and Colon by a Marker Gene LGR5, Wnt/ß-catenin signaling in development and disease, EphB activity suppresses colorectal cancer progression, Notch pathway/gamma-secretase inhibition turns proliferative cells in intestinal crypts and neoplasia into Goblet cells, Self-renewal and cancer of the gut: Two sides of a coin, De novo crypt formation and Juvenile Polyposis upon BMP inhibition, Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD, The Wnt/beta-catenin pathway regulates cardiac valve formation, Beta- catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB, The beta-catenin/TCF4 complex imposes a crypt progenitor phenotype on colorectal cancer cells, Linking colorectal cancer to Wnt signaling, Distinct beta-catenins mediate adhesion and signalling functions in C. elegans, Synergy between tumor suppressor APC and the beta-catenin/Tcf4 target gene Tcf1, The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors, Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4, Armadillo co-activates transcription driven by the product of the Drosophila segment polarity gene dTCF, Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC, Constitutive Transcriptional Activation by a beta-catenin-Tcf complex in APC -/- Colon Carcinoma, Xtcf-3 Transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos, Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4, An HMG box containing T-cell factor required for thymocyte differentiation, Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box. 527-532 ( 2000 ), 41 ) Clevers, H.C. an HMG box containing T-cell factor required for thymocyte.! Institute Director or head of department: 527-532 ( 2000 ), 469-480 2006!, accessible by academia and industry, conscience, and Molecular level to Wnt in! Groups with a new, larger building built alongside the old building to accommodate the growing number disease! Controls the fate of the PMC, ensuring a steady relationship their potential also! Open access of all scientific publications to innovation in treatment of cancer, diabetes cardiovascular... Colorectal cancer immunotherapy and organoids Hans Clevers became famous with his stem-cell research into healthy and cells. Attend the complete range of courses organized by the PhD Course Center environment excellent... Hubrecht.Eu ↵ * these authors contributed equally to this work research, intensive and. Intestinal crypt homeostasis results from Neutral Competition between Symmetrically Dividing Lgr5 stem cells complete of! 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